Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

  title={Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment},
  author={Lan Thi Hanh Phi and Ita Novita Sari and Ying-Gui Yang and Sanghyun Lee and Nayoung Jun and Kwang Seock Kim and Yun Kyung Lee and Hyog Young Kwon},
  journal={Stem Cells International},
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand the characteristics and mechanisms by which CSCs display resistance to therapeutic agents. In this review, we highlight the key features and mechanisms that regulate CSC function in drug resistance as… 

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