Cancer Stem Cells: Repair Gone Awry?

  title={Cancer Stem Cells: Repair Gone Awry?},
  author={Fatima A Rangwala and Alessia Omenetti and Anna Mae Diehl},
  booktitle={Journal of oncology},
Because cell turnover occurs in all adult organs, stem/progenitor cells within the stem-cell niche of each tissue must be appropriately mobilized and differentiated to maintain normal organ structure and function. Tissue injury increases the demands on this process, and thus may unmask defective regulation of pathways, such as Hedgehog (Hh), that modulate progenitor cell fate. Hh pathway dysregulation has been demonstrated in many types of cancer, including pancreatic and liver cancers, in… CONTINUE READING
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