Cancer Site-Specific Isoforms of ENOX2 (tNOX), A Cancer-Specific Cell Surface Oxidase

@article{Hostetler2008CancerSI,
  title={Cancer Site-Specific Isoforms of ENOX2 (tNOX), A Cancer-Specific Cell Surface Oxidase},
  author={Brandon Hostetler and Nicole A. Weston and Chinpal Kim and Dorothy M. Morr{\'e}},
  journal={Clinical Proteomics},
  year={2008},
  volume={5},
  pages={46-51}
}
All neoplastic cells express one or more members of a unique family of tumor-associated cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ENOX2 or tNOX proteins) that are characteristically blocked by quinone site inhibitors with anti-cancer activity. Analyses using two-dimensional gel electrophoresis with detection on western blots using a pan ENOX2 recombinant antibody revealed unique ENOX2 isoforms or unique combinations of isoforms of… CONTINUE READING
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