Cancer Neoantigens and Applications for Immunotherapy.

  title={Cancer Neoantigens and Applications for Immunotherapy.},
  author={Alexis Desrichard and Alexandra Snyder and Timothy A. Chan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={22 4},
Recent advances in immune checkpoint blockade therapy have revolutionized the treatment of cancer. Tumor-specific antigens that are generated by somatic mutation, neoantigens, can influence patient response to immunotherapy and contribute to tumor shrinkage. Recent evidence demonstrating the success of checkpoint blockade immunotherapy in boosting T-cell reactivity against patient-specific neoantigens constitutes a strong rationale for the development of personalized vaccines against these… CONTINUE READING
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