Cancer Invasion to Auerbach’s Plexus is an Important Prognostic Factor in Patients with pT3-pT4 Colorectal Cancer

@article{Fujita2007CancerIT,
  title={Cancer Invasion to Auerbach’s Plexus is an Important Prognostic Factor in Patients with pT3-pT4 Colorectal Cancer},
  author={Shin Fujita and Yukihiro Nakanisi and Hirokazu Taniguchi and Seiichiro Yamamoto and Takayuki Akasu and Yoshihiro Moriya and Tadakazu Shimoda},
  journal={Diseases of the Colon \& Rectum},
  year={2007},
  volume={50},
  pages={1860-1866}
}
PurposeBy defining perineural invasion of colorectal cancer as invasion to Auerbach’s plexus, we examined the usefulness of this pathologic finding as a prognostic factor.MethodsA total of 509 consecutive patients who underwent curative surgery for pT3 or pT4 colorectal cancer between May 1997 and December 2001 were reviewed. All the surviving patients were followed for more than five years. All the pathologic findings, including perineural invasion, were described prospectively in the… 
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References

SHOWING 1-10 OF 26 REFERENCES
Lymphovascular and neural invasion in low-lying rectal carcinoma.
TLDR
The results suggest that postoperative assessment of venous and neural invasion may provide valuable information to better determine which patients with low rectal cancers would benefit from adjuvant treatment.
Venous and nerve invasion as prognostic factors in postoperative survival of patients with resectable cancer of the rectum
TLDR
The histopathologic and clinical findings in 682 patients with carcinoma of the rectum have been analyzed and revealed the importance of the invasion of veins as well as of nerves.
Venous and neural invasion as predictors of recurrence in rectal adenocarcinoma
TLDR
Examining for the presence of venous and neural invasion gives reliable prediction of recurrences after radical resection of rectal cancer, found to be the third strongest independent predictor of metastasis, after lymph node status and extent of local tumor infiltration.
Prognostic value of additional pathological variables for long-term survival after curative resection of rectal cancer.
TLDR
Patients with lymphatic and perineural invasion have a higher risk for rectal cancer related death after curative resection and examination of these variables should be an important step in detecting patients with a poorer prognosis.
Identifying Stage B colorectal cancer patients at high risk of tumor recurrence and death
TLDR
Further study of prognostic indicators might result in an algorithm to distinguish Stage B cases at high risk of tumor recurrence and death and such patients could be included in future trials of adjuvant therapies.
Recurrence and survival after surgical management of rectal cancer.
Postoperative survival of patients with potentially curable cancer of the colon
TLDR
Using a model including all prognostic factors, sex and Dukes' classification were not found to be associated with survival, and the invasion of veins was almost always associated with invasion of nerves.
Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer.
TLDR
Vessel count and expression of VEGF may be useful for predicting distant recurrence in patients with node-negative colon cancer.
Prognostic Variables for Cancer-Related Survival in Node-Negative Colorectal Carcinomas
Background/Aim: The efficacy of adjuvant treatment in node-negative colorectal carcinoma is unproven. The purpose of this study was to analyze the prognostic value of routinely detectable
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