Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

  title={Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion},
  author={Robert D. Schreiber and Lloyd J. Old and Mark J. Smyth},
  pages={1565 - 1570}
Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are… 
From Cancer Immunoediting to New Strategies in Cancer Immunotherapy: The Roles of Immune Cells and Mechanics in Oncology.
The concept of cancer immunoediting is reviewed with an emphasis on biomechanics and a summary on current immunotherapies and potential new strategies is concluded with a summary of immunotherapy design.
From mice to humans: developments in cancer immunoediting.
The characteristics of the adaptive immune resistance tumor microenvironment are described and data obtained in mouse and human settings are discussed and the role of other immune cells and factors influencing the effector function of tumor-specific CD8+ T cells are covered.
Novel “Elements” of Immune Suppression within the Tumor Microenvironment
Two elements from the periodic table—oxygen and potassium—that suppress the immune system in previously unappreciated ways are highlighted.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth
An overview of T lymphocyte-driven control of tumor growth is given and the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting are discussed with respect to recent clinical developments of immunotherapies.
Cancer Dormancy: A Regulatory Role for Endogenous Immunity in Establishing and Maintaining the Tumor Dormant State
It is suggested that anticancer therapies aiming to stimulate the endogenous antitumor responses provide the concept of the therapeutic management of cancer.
The immune system and inflammation in breast cancer
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges
The fundamental knowledge of the phenomena is discussed and an overview of the next-generation immunotherapies in the pipeline is provided to provide a broader understanding of cancer immunosurveillance and immunoediting.


Natural innate and adaptive immunity to cancer.
Current experimental and human clinical data supporting a cancer immunoediting process that provide the fundamental basis for further study of immunity to cancer and for the rational design of immunotherapies against cancer are discussed.
The three Es of cancer immunoediting.
The history of the cancer immunosurveillance controversy is summarized and its resolution and evolution into the three Es of cancer immunoediting--elimination, equilibrium, and escape are discussed.
Does the immune system see tumors as foreign or self?
  • D. Pardoll
  • Biology, Medicine
    Annual review of immunology
  • 2003
To elude immune surveillance, tumors must develop mechanisms that block the elaboration and sensing of proinflammatory danger signals, thereby shifting the balance from activation to tolerance induction.
Immune surveillance of tumors.
This work provides the basis for further study of natural immunity to cancer and for rational use of this information in the design of immunotherapies in combination with other conventional cancer treatments.
Adaptive immunity maintains occult cancer in an equilibrium state
It is demonstrated that equilibrium occurs, is mechanistically distinguishable from elimination and escape, and that neoplastic cells in equilibrium are transformed but proliferate poorly in vivo, and it is shown that tumour cells inilibrium are unedited but become edited when they spontaneously escape immune control and grow into clinically apparent tumours.
Immune therapy for cancer.
Novel approaches to immune-based cancer treatment strive to augment antitumor immune responses by expanding tumor-reactive T cells, providing exogenous immune-activating stimuli, and antagonizing regulatory pathways that induce immune tolerance.