Cancer Genes Hypermethylated in Human Embryonic Stem Cells

  title={Cancer Genes Hypermethylated in Human Embryonic Stem Cells},
  author={Vincenzo Calvanese and Ang{\'e}lica Horrillo and Abdelkrim Hmadcha and Beatriz Suarez-Alvarez and Agust{\'i}n F Fern{\'a}ndez and Ester Lara and S. Casado and P. J. Men{\'e}ndez and Clara Bueno and Javier Garc{\'i}a-Castro and Ruth {\'A}gueda Rubio and P Lapunzina and Miguel Alaminos and Lodovica Borghese and Stefanie Terstegge and Neil J. Harrison and Harry D. M. Moore and Oliver Bruestle and Carlos L{\'o}pez-Larrea and Peter W. Andrews and Bernat Soria and Manel Esteller and Mario F Fraga},
  journal={PLoS ONE},
  pages={425 - 432}
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in… CONTINUE READING