Cancer Cytogenetics: Methodology Revisited

  title={Cancer Cytogenetics: Methodology Revisited},
  author={Thomas Wan},
  booktitle={Annals of laboratory medicine},
The Philadelphia chromosome was the first genetic abnormality discovered in cancer (in 1960), and it was found to be consistently associated with CML. The description of the Philadelphia chromosome ushered in a new era in the field of cancer cytogenetics. Accumulating genetic data have been shown to be intimately associated with the diagnosis and prognosis of neoplasms; thus, karyotyping is now considered a mandatory investigation for all newly diagnosed leukemias. The development of FISH in… CONTINUE READING