Cancer Chemopreventive and Tumoricidal Properties of Saffron (Crocus sativus L.)

@article{Abdullaev2002CancerCA,
  title={Cancer Chemopreventive and Tumoricidal Properties of Saffron (Crocus sativus L.)},
  author={Fikrat I. Abdullaev},
  journal={Experimental Biology and Medicine},
  year={2002},
  volume={227},
  pages={20 - 25}
}
  • F. Abdullaev
  • Published 2002
  • Biology, Medicine
  • Experimental Biology and Medicine
Since cancer is the most common cause of death in the world population, the possibility that readily available natural substances from plants, vegetables, herbs, and spices may be beneficial in the prevention of cancer warrants closer examination. Saffron in filaments is the dried, dark red stigmata of Crocus sativus L. flowers and it is used as a spice, food colorant, and a drug in medicine. A growing body of research has demonstrated that saffron extract itself and its main constituents, the… Expand
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Saffron (dimethyl-crocetin) disrupts DNA-protein interactions e.g. topoisomerases II, important for cellular DNA synthesis, according to results indicated significant inhibition in the synthesis of nucleic acids but not protein synthesis. Expand
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TLDR
A novel glycoconjugate isolated from saffron corm extracts shows remarkable cytotoxic activity on cultured human cancer cells (HeLa), suggesting that cytotoxicity is mediated by extracellular fluid uptake. Expand
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Research into the chemical composition of saffron, the dried stigmas of Crocus sativus, has seen a renaissance in recent years. Different HPLC protocols for the analysis of saffron constituents haveExpand
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The studies indicate the antioxidant activity of saffron, which enhanced its antitumor activity towards Sarcoma-180 and Ehrlich ascites carcinoma solid tumors in mice and stimulated non-specific proliferation of lymphocytes in vitro. Expand
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TLDR
There is strong evidence indicating that callus cultures of saffron corm also synthesize glycoconjugate, which is cytotoxic against human cervical epithelioid carcinoma cells and consists of approximately 90% carbohydrate and 10% protein. Expand
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