Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

@article{Jang1997CancerCA,
  title={Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes},
  author={Meishiang Jang and Lining Cai and George Udeani and Karla Slowing and Cathy F Thomas and Chris Beecher and Harry H. S. Fong and N. R. Farnsworth and A. Douglas Kinghorn and Rajendra G Mehta and Richard C. Moon and John M. Pezzuto},
  journal={Science},
  year={1997},
  volume={275},
  pages={218 - 220}
}
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia… 
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