Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

  title={Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes},
  author={Meishiang Jang and Lining Cai and George Udeani and Karla Slowing and Cathy F Thomas and Chris Beecher and Harry H. S. Fong and N. R. Farnsworth and A. Douglas Kinghorn and Rajendra G Mehta and Richard C. Moon and John M. Pezzuto},
  pages={218 - 220}
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia… 

The potential of resveratrol against human gliomas

Current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas is discussed.

Resveratrol: a review of preclinical studies for human cancer prevention.

Effects of resveratrol, an important component of red wine, on intestinal cancer development

Results showed that dietary grape extract significantly decreased the incidence and multiplicity of tumors in small intestine in rats and resveratrol significantly inhibited cell viability and cell proliferation in Caco-2 cells.

Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent?

Mechanisms via which resveratrol is thought to exert chemopreventive efficacy are inhibition of cyclooxygenase enzymes, inhibition of angiogenesis, modulation of drug metabolising enzymes, antioxidation and alterations of cell cycle components and apoptotic machinery.

Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants

Investigation of the effect of resveratrol on angiogenesis in vitro and ex vivo found that it directly inhibited human umbilical vein endothelial cell growth and decreased the gelatinolytic activities of matrix metalloproteinase-2.

Potential of resveratrol in anticancer and anti-inflammatory therapy.

Resveratrol possesses good potential to be used as an adjunctive or alternative therapy for cancer and inflammatory diseases and has been shown to produce no adverse effects, even when consumed at high concentrations.

Resveratrol chemoprotective effect and COX 2 down regulation in tumor suppression in DMBA induced breast cancer in female Sprague Dawley rats

Resveratrol (trans-3,5,4′-trihydroxystilbene;), an essential element of grapes, berries and peanuts has risen as an “age-prolongation factor”. Subsequently, the compound was considered a

Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials

Directions for future resveratrol research are described to establish its activity and utility as a human cancer preventive and therapeutic drug.

Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.

Together, the data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent, and clinical investigations are warranted once efficacy and safety in animal models have been established.



Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase

Four active rotenoids obtained from the African plant Mundulea sericea were obtained and appear to function by a unique mechanism at the level of ODC messenger RNA expression, which can be regarded as promising new chemopreventive or anticancer agents.

Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model.

It is concluded that the HL-60 cell differentiation system is a valid and useful model for the discovery of natural product cancer chemopreventive or chemotherapeutic agents.

Screening of potential chemopreventive agents using biochemical markers of carcinogenesis.

Agents that were positive in these assays may inhibit the carcinogenesis process by similar mechanisms in humans and are identified as candidates for development as chemopreventive agents.

A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity.

The combined use of these assays should aid in the discovery of antimutagenic agents that have cancer chemopreventive potential.

Chemoprevention of cancer with retinoids.

The importance of retinoids for chemoprevention of cancer has received further emphasis with the finding that retinoids can suppress in vitro expression of the malignant phenotype, whether it be

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

It is reported that sulforaphane and three synthetic analogues, designed as potent phase 2 enzyme inducers, block the formation of mammary tumors in Sprague-Dawley rats treated with single doses of 9,10-dimethyl-1,2-benzanthracene.

The Production of Resveratrol (3,5,4'-trihydroxystilbene) by Grape Berries in Different Developmental Stages

The decrease of resveratrol production during maturation was confirmed by the fact that there is a clear negative correlation between the resver atrol content of grape skin and the developmental stage of berries measured by the sugar concentration of juice.

Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism.

It was found that intraperitoneal or oral administration of resveratrol or piceid reduced triglyceride synthesis from 14C-palmitate in the liver of mice and these stilbene components did not affect hormone-induced lipolysis in fat cells from rat eqididymal adipose tissue.