Cancer Biology and Signal Transduction Ponatinib Induces Apoptosis in Imatinib-Resistant Human Mast Cells by Dephosphorylating Mutant D 816 V KIT and Silencing b-Catenin Signaling

@inproceedings{Jin2014CancerBA,
  title={Cancer Biology and Signal Transduction Ponatinib Induces Apoptosis in Imatinib-Resistant Human Mast Cells by Dephosphorylating Mutant D 816 V KIT and Silencing b-Catenin Signaling},
  author={Bei Jin and Ke Ding and Jingxuan Pan},
  year={2014}
}
Gain-of-function mutations of membrane receptor tyrosine kinase KIT, especially gatekeeper D816V point mutation in KIT, render kinase autoactivation, disease progression, and poor prognosis. D816V KIT is found in approximately 80% of the patients with systemic mastocytosis, and is resistant to the first and second generations of tyrosine kinase inhibitors (TKI). The purpose of this investigation was aimed at exploring whether ponatinib (AP24534), a novel effective TKI against T315I Bcr-Abl, was… CONTINUE READING

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