Cancer Biology and Signal Transduction Interferon-b Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells

@inproceedings{Happold2014CancerBA,
  title={Cancer Biology and Signal Transduction Interferon-b Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells},
  author={Caroline Happold and Patrick Roth and Manuela Silginer and Ana-Maria Florea and Katrin Lamszus and Karl Frei and Ren{\'e} Deenen and Guido Reifenberger and Michael Weller},
  year={2014}
}
Glioblastoma is the most common malignant brain tumor in adults and characterized by a poor prognosis. Glioma cells expressing O-methylguanine DNA methyltransferase (MGMT) exhibit a higher level of resistance toward alkylating agents, including the standard of care chemotherapeutic agent temozolomide. Here, we demonstrate that long-term glioma cell lines (LTL) as well as glioma-initiating cell lines (GIC) express receptors for the immune modulatory cytokine IFN-b and respond to IFN-b with… CONTINUE READING