Cancer Biology and Signal Transduction Inhibition of mTOR Signaling Reduces PELP 1-Mediated Tumor Growth and Therapy Resistance

@inproceedings{Gonugunta2014CancerBA,
  title={Cancer Biology and Signal Transduction Inhibition of mTOR Signaling Reduces PELP 1-Mediated Tumor Growth and Therapy Resistance},
  author={Vijay Kumar Gonugunta and Gangadhara Reddy Sareddy and Samaya Rajeshwari Krishnan and Valerie Cortez and Sudipa Saha Roy and Rajeshwar Rao Tekmal and Ratna K Vadlamudi},
  year={2014}
}
Proline, Glutamic acid-, and Leucine-rich Protein 1 (PELP1) is a proto-oncogene that modulates estrogen receptor (ER) signaling. PELP1 expression is upregulated in breast cancer, contributes to therapy resistance, and is a prognostic marker of poor survival. In a subset of breast tumors, PELP1 is predominantly localized in the cytoplasm and PELP1 participates in extranuclear signaling by facilitating ER interactions with Src and phosphoinositide 3-kinase (PI3K). However, the mechanism by which… CONTINUE READING
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