Cancer-Associated Mutations in Endometriosis without Cancer.

@article{Anglesio2017CancerAssociatedMI,
  title={Cancer-Associated Mutations in Endometriosis without Cancer.},
  author={Michael S Anglesio and Nickolas Papadopoulos and Ayse Ayhan and Tayyebeh M Nazeran and Micha{\"e}l No{\"e} and Hugo M. Horlings and A Fontem Lum and Si{\^a}n Jones and Janine Senz and Tamer Seckin and J Ho and R Wu and Vivian Lac and Hiroshi Ogawa and Basile Tessier-Cloutier and Rami Alhassan and A Wang and Yuxuan Wang and Joshua David Cohen and Fontayne Wong and Adnan Hasanovic and Natasha L Orr and Ming Zhang and Maria Popoli and Wyatt McMahon and Laura D Wood and Austin Mattox and Catherine Allaire and James H Segars and Christina Williams and Cristian Tomasetti and Niki Boyd and Kenneth W. Kinzler and C. Blake Gilks and Luis D{\'i}az and T. Wang and Bert Vogelstein and Paul J. Yong and David G. Huntsman and Ie-Ming Shih},
  journal={The New England journal of medicine},
  year={2017},
  volume={376 19},
  pages={1835-1848}
}
BACKGROUND Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS We analyzed deeply infiltrating endometriotic lesions from 27 patients by means of exomewide sequencing (24 patients) or cancer-driver targeted… CONTINUE READING

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