Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion

@inproceedings{Jia2013CancerAssociatedFF,
  title={Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion},
  author={Chang-chang Jia and Tian-tian Wang and Wei Liu and Bin-sheng Fu and Xuefeng Hua and Guoying Wang and Tuan-jie Li and Xing Li and Xiang-yuan Wu and Yan F. Tai and Jie Zhou and Guihua Chen and Qi Zhang},
  booktitle={PloS one},
  year={2013}
}
Cancer-associated fibroblasts (CAFs) are reported to support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion in most solid tumors. However, the roles of CAFs in the liver cancer microenvironment have not been thoroughly studied. In our previous study, we successfully isolated CAFs from hepatocellular carcinoma (HCC) (H-CAFs) and proved that H-CAFs suppressed the activation of NK cells and thereby created favorable conditions for HCC progression. In our present… CONTINUE READING
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