Cancer‐related fatigue

  title={Cancer‐related fatigue},
  author={Ann M Berger and Lynn H. Gerber and Deborah K. Mayer},
Cancer‐related fatigue (CRF) has been documented as 1 of the most distressing symptoms reported by breast cancer survivors. CRF affects functioning and impacts quality of life. Possible causal factors include physical conditions, affective and cognitive states, proinflammatory cytokines, and metabolic factors. Several common problems are associated with CRF in women with breast cancer, including treatment side effects, obesity, arm/upper quadrant symptoms, sleep disturbances, psychological… 

Nausea and disturbed sleep as predictors of cancer-related fatigue in breast cancer patients: a multicenter NCORP study

This study showed a high prevalence of clinically relevant CRF in breast cancer patients following their initial chemotherapy, and that nausea severity, disturbed sleep, pre-treatment CRF, and age were significant predictors of symptom.

Cancer-Related Fatigue in Cancer Survivorship.

Cancer-Related Fatigue and Associated Factors in Young Adult Cancer Patients.

Caregivers should assess CRF in AYAs independent of their medical characteristics, and reducing additional burdens may represent a way of reducing CRf in AYA cancer patients.

Factors of Cancer-Related Fatigue in Patients with Malignant Diseases

It is concluded that the symptoms of fatigue, exhaustion and pain are considered the most common complaints in patients with oncologic pathology during and after treatment, whose manifestations may be physical, cognitive and emotional.

Cancer-Induced Fatigue and Cachexia

Research into the various hypotheses discussed in this chapter would greatly benefit cancer patients experiencing fatigue, including muscle wasting, involving both the degradation of muscle and the inhibition of muscle regeneration.

Management of fatigue following breast cancer treatment

A literature review of the studies published in the last 5 years on management of CRF and breast cancer patients distinguished CRF during and after oncological therapy and examined both pharmacological and nonpharmacological interventions.

Commentary: Harnessing the Parent Perspective to Understand Cancer-Related Fatigue in Adolescents.

As a result of medical innovations, survival rates for pediatric cancer are around 83% today (Siegel, 2016). Unfortunately, two thirds of survivors of childhood cancer will experience long-term side

Factors related to clinically relevant fatigue in disease-free stomach cancer survivors and expectation–outcome consistency

In disease-free stomach cancer survivors, CRF is a common problem that is strongly associated with quality of life and other symptoms, and current depression, poor performance, and perceived understanding regarding postoperative condition are important CRF risk factors.

Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study

Autonomic regulation might have an independent, reductive influence on global fatigue, cognitive fatigue and – together with self-regulation – it seems to have a protective influence on anxiety and depression.

Cancer related fatigue and self-care agency: a multicentre survey of patients receiving chemotherapy.

Understanding the link between self-care agency and CRF levels will help practitioners to better support individuals on the cancer journey and lead to more individualised and tailored approaches to CRF.



Cancer‐Related Fatigue: State of the Science

  • S. Mitchell
  • Psychology
    PM & R : the journal of injury, function, and rehabilitation
  • 2010

Integrative nonpharmacologic behavioral interventions for the management of cancer-related fatigue.

An overview of current research on the relative merits of integrative nonpharmacologic behavioral interventions for the effective clinical management of cancer-related fatigue is provided and recommendations for future research are made.

Nonpharmacologic supportive strategies to promote quality of life in patients experiencing cancer-related fatigue: a systematic review.

The results show that exercises (e.g., home-based exercise, supervised exercise), education and counseling, sleep therapy, and complementary therapy are feasible as effective nonpharmacologic supportive interventions to improve QOL in patients with breast cancer suffering from CRF.

Cancer-related fatigue: a systematic and meta-analytic review of non-pharmacological therapies for cancer patients.

It is suggested that vigor and vitality are distinct phenomena from CRF with regard to responsiveness to intervention, and multimodal exercise and walking programs, restorative approaches, supportive-expressive, and cognitive-behavioral psychosocial interventions show promising potential for ameliorating CRF.

Factors predicting clinically significant fatigue in women following treatment for primary breast cancer

Fatigue increases significantly following the treatment of primary breast cancer, and predictors of CSF include high BMI and WBC count, increase in limb volume, and low level of physical activity.

Impact of fatigue on quality of life in oncology patients.

  • G. Curt
  • Medicine
    Seminars in hematology
  • 2000

Pharmacological treatments for fatigue associated with palliative care.

Based on limited evidence, it is unable to recommend a specific drug for treatment of fatigue in palliative care patients and recent fatigue research seems to focus on modafinil, which may be beneficial although there is no evidence currently.

Progress toward guidelines for the management of fatigue.

Experienced by most patients as an extremely frustrating state of chronic energy depletion, it leads to loss of productivity which can reduce self-esteem and places people at risk for being questioned about the veracity of their complaints, particularly during the post-treatment, disease-free survival period.

Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis

The results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type.