Cancer‐associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo

@article{Yokoyama2013CancerassociatedUO,
  title={Cancer‐associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo},
  author={Y. Yokoyama and M. Hieda and Yu Nishioka and Ayaka Matsumoto and Satomi Higashi and H. Kimura and Hirofumi Yamamoto and M. Mori and Shuji Matsuura and N. Matsuura},
  journal={Cancer Science},
  year={2013},
  volume={104},
  pages={889 - 895}
}
Global histone modification patterns correlate with tumor phenotypes and prognostic factors in multiple tumor types. Recent studies suggest that aberrant histone modifications play an important role in cancer. However, the effects of global epigenetic rearrangements on cell functions remain poorly understood. In this study, we show that the histone H3 lysine 9 (H3K9) methyltransferase SUV39H1 is clearly involved in regulating cell migration in vitro. Overexpression of wild‐type SUV39H1, but not… Expand
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity
HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.
HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.
Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 44 REFERENCES
...
1
2
3
4
5
...