Cancer: an old disease, a new disease or something in between?

  title={Cancer: an old disease, a new disease or something in between?},
  author={A. Rosalie David and Michael R. Zimmerman},
  journal={Nature Reviews Cancer},
In industrialized societies, cancer is second only to cardiovascular disease as a cause of death. The history of this disorder has the potential to improve our understanding of disease prevention, aetiology, pathogenesis and treatment. A striking rarity of malignancies in ancient physical remains might indicate that cancer was rare in antiquity, and so poses questions about the role of carcinogenic environmental factors in modern societies. Although the rarity of cancer in antiquity remains… 
An old disease, a new disease or something in between: evidence from China
It is proposed that cancer was rare in antiquity, however, this conclusion might need further verification as they neglected the literature and evidence from China.
Cancer is an ancient disease?
The rarity of that diagnosis in the tens of thousands of skeletal remains and thousands of mummies that have been examined supports the view that most cancers in the authors' modern populations are due to man-made factors.
Gastric Cancer in History: A Perspective Interdisciplinary Study
The historical evolving knowledge of the disease along the centuries on the gastroenterological, pharmacological, and surgical fields is examined, defining how gastric cancer became an increasingly curable disease.
Precision medicine: the foundation of future cancer therapeutics
Several lines of evidence strongly support the idea that precision oncology could likely benefit more patients compared with traditional chemotherapies, and many creative and bold ideas of precision medicine have not yet made the transition from the lab bench to the clinic and need to be more fully evaluated in small clinical studies.
On the Antiquity of Cancer: Evidence for Metastatic Carcinoma in a Young Man from Ancient Nubia (c. 1200BC)
A male, young-adult individual from the archaeological site of Amara West in northern Sudan (c. 1200BC) displaying multiple, mainly osteolytic, lesions is presented, which represents the earliest complete example in the world of a human who suffered metastatic cancer to date.
A Disease Without History? Evidence for the Antiquity of Head and Neck Cancers
It is established that cancers of the head and neck have long been present, and perhaps even prevalent, in human societies, and the paleopathological record was found to contain surprisingly abundant evidence.
Can examples of ancient human bone neoplasms inform current biomedical bone cancer research
This essay evaluates the paleopathological study of metastatic carcinoma in relevance to modern biomedical studies, addressing whether the available evidence of these investigations can reliably be used in the development of new methods of bone cancer treatment.
Homeostatic Imbalance and Colon Cancer: The Dynamic Epigenetic Interplay of Inflammation, Environmental Toxins, and Chemopreventive Plant Compounds
The idea that homeostasis has been redefined within just a few generations, and that diseases such as colorectal cancer are the result of fluctuating physiological and molecular imbalances is explored.


An experimental study of mummification pertinent to the antiquity of cancer
The absence of tumors in ancient tissues must be considered a reflection of a markedly lower incidence than in the modern population of the United States, in which cancer accounts for approximately 17% of all deaths.
Antiquity of cancer
  • L. Capasso
  • Biology
    International journal of cancer
  • 2005
It would seem likely that genetic changes in humans caused biological variations, including susceptibility to cancer over time, and socio-cultural changes also changed the patterns of human cancer.
The paleopathology of the cardiovascular system.
An experimental study suggests that the potential exists for identifying a wide range of cardiovascular pathologic conditions in mummified remains and the antiquity and ubiquity of arteriosclerotic heart disease is considered in terms of pathogenesis.
Metastatic tumor of bone in a Tiahuanaco female.
Six cases of metastatic tumor in the paleopathology literature of the Americas were reviewed by Steinbock,1 and an additional study on malignant melanoma was reported by Urteaga and Pack.
Metastatic carcinoma in a leper skeleton from a Medieval cemetery in Chichester England
A case from a Medieval site in Chichester, England exhibits bone lesions and patterns of skeletal involvement indicative of both leprosy and metastatic cancer.
Paleohistopathology of bone: a new approach to the study of ancient diseases.
  • M. Schultz
  • Medicine
    American journal of physical anthropology
  • 2001
As a reliable diagnosis is the basis not only of the study of case reports but also of the etiology and epidemiology of diseases in ancient populations, paleopathologists would be well-advised to employ histological analysis for their research, to avoid false diagnoses.
On the antiquity of melanoma
Most interesting testimony to the antiquity of this tumor is exhibited in several mummies of pre‐Colombian Incas of Peru, some estimated to be 2,400 years old, which show diffuse metastases to bones, particularly of the skull and extremities.
The figures and tables present the statistics resulting from application of these principles to various forms of cancer among varying populations.
A possible histiocytoma in an Egyptian mummy.
The finding of a possible histiocytoma in the skin of the heel of an Egyptian mummy and the satisfactory preservation of cutaneous histologic and pathologic features in mummies should encourage the performance of additional studies.
Identification of Pathological Conditions in Human Skeletal Remains
This book provides essential text and materials on bone pathology, which will improve the diagnostic ability of those interested in human dry bone pathology and provides time depth to the understanding of the effect of disease on past human populations.