Cancer: Integrated epigenomic analysis sheds light on role of BMP4 in regulating cisplatin sensitivity in gastric cancer

@article{Wood2012CancerIE,
  title={Cancer: Integrated epigenomic analysis sheds light on role of BMP4 in regulating cisplatin sensitivity in gastric cancer},
  author={Natalie J. Wood},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2012},
  volume={9},
  pages={301-301}
}
  • Natalie J. Wood
  • Published 22 May 2012
  • Biology, Medicine
  • Nature Reviews Gastroenterology &Hepatology
Cancer: Integrated epigenomic analysis sheds light on role of BMP4 in regulating cisplatin sensitivity in gastric cancer 

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References

Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer

TLDR
Epigenomic analysis identified bone morphogenetic protein 4 (BMP4) as an epigenetically regulated gene highly expressed in cisplatin-resistant lines, and functional assays confirmed that BMP4 is necessary and sufficient for the expression of several prooncogenic traits, likely mediated through stimulation of the epithelial-mesenchymal transition.