Cancer: GSK3α is a new target in leukaemia

Modulating the phosphorylation of mutant huntingtin might slow the progression of Huntington’s disease (HD). This study showed that intraventricular infusion of GM1 ganglioside into a mouse model of HD (YAC128 mice) caused phosphorylation of mutant huntingtin at specific amino acid residues that are known to attenuate huntingtin toxicity. Moreover, GM1… CONTINUE READING