Cancer, inflammation and the AT1 and AT2 receptors

  title={Cancer, inflammation and the AT1 and AT2 receptors},
  author={Gary Robert Smith and Sotiris Missailidis},
  journal={Journal of Inflammation (London, England)},
  pages={3 - 3}
The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer. This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor through systemic oxidative stress and hypoxia mechanisms, thereby triggering chronic inflammatory processes to remodel surrounding tissue and subdue the immune system. Based on… CONTINUE READING
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