Cancel the denosumab holiday

  title={Cancel the denosumab holiday},
  author={Michael R Mcclung},
  journal={Osteoporosis International},
Denosumab, a fully human IgG2 anti-RANK ligand antibody, quickly and substantially inhibits bone remodeling [1]. As expected by the pharmacology of denosumab, this inhibition of remodeling is completely reversible upon stopping treatment [2]. In clinical trials, discontinuing therapy after 2 years results in a rapid rebound in bone turnover markers, raising concern about whether that high remodeling rate and consequent rapid bone loss that occurs has clinical relevance beyond a simple waning of… CONTINUE READING
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AbrahamsenB (2015)Denosumab: a novel antiresorptive drug for osteoporosis

  • E Suresh
  • Cleve Clin J Med
  • 2015
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