Canalostomy as a surgical approach for cochlear gene therapy in the rat.

@article{Gassner2012CanalostomyAA,
  title={Canalostomy as a surgical approach for cochlear gene therapy in the rat.},
  author={Davina Gassner and Dianne Durham and Susanna C Pfannenstiel and D. Brough and Hinrich Staecker},
  journal={Anatomical record},
  year={2012},
  volume={295 11},
  pages={1830-6}
}
This article presents a unique approach for the delivery of gene therapy vectors into the cochlea of the laboratory rat. Mice and guinea pigs are established in vivo models for cochlear gene therapy each of which has distinct advantages and disadvantages. The rat has some of the molecular advantages of a mouse model combined with size advantages for… CONTINUE READING