Canaloplasty: Circumferential viscodilation and tensioning of Schlemm's canal using a flexible microcatheter for the treatment of open‐angle glaucoma in adults: Interim clinical study analysis

@article{Lewis2007CanaloplastyCV,
  title={Canaloplasty: Circumferential viscodilation and tensioning of Schlemm's canal using a flexible microcatheter for the treatment of open‐angle glaucoma in adults: Interim clinical study analysis},
  author={Richard Alan Lewis and Kurt von Wolff and Manfred R. Tetz and Norbert Korber and John R. Kearney and Bradford J. Shingleton and Thomas W. Samuelson},
  journal={Journal of Cataract and Refractive Surgery},
  year={2007},
  volume={33},
  pages={1217–1226}
}
PURPOSE: To evaluate the safety and efficacy of circumferential viscodilation and tensioning of the inner wall of Schlemm's canal in a new surgical procedure for the treatment of open‐angle glaucoma (OAG). SETTING: Fourteen clinical sites in the United States and Germany. METHODS: In this international multicenter prospective study of adult patients with OAG having glaucoma surgery, patients with qualifying preoperative intraocular pressure (IOP) of at least 16 mm Hg or higher and open angles… Expand
Canaloplasty: Circumferential viscodilation and tensioning of Schlemm canal using a flexible microcatheter for the treatment of open‐angle glaucoma in adults: Two‐year interim clinical study results
TLDR
Canonoplasty was safe and effective in reducing IOP in adult patients with OAG and medication use results at all time points were statistically significant versus baseline (P <.001). Expand
Canaloplasty: Three‐year results of circumferential viscodilation and tensioning of Schlemm canal using a microcatheter to treat open‐angle glaucoma
TLDR
Intraocular pressure and medication use results in all eyes were significantly decreased from baseline at every time point and canaloplasty led to a significant and sustained IOP reduction in adult patients with open‐angle glaucoma and had an excellent short‐ and long‐term postoperative safety profile. Expand
Circumferential viscodilation and tensioning of Schlemm canal (canaloplasty) with temporal clear corneal phacoemulsification cataract surgery for open‐angle glaucoma and visually significant cataract: One‐year results
TLDR
Circumferential viscodilation and tensioning of Schlemm canal combined with clear corneal phacoemulsification and posterior chamber intraocular lens (IOL) implantation was a safe and effective procedure to reduce intraocular pressure in adult patients with OAG. Expand
Circumferential viscocanalostomy with suture tensioning in Schlemm canal (canaloplasty) – One year experience
TLDR
Ultrasound biomicroscopy assisted Canaloplasty, alone or combined, provided a sustained IOP reduction to medium-low levels, led to a decrease in the number of drugs and had a good safety profile, making this a good alternative to trabeculectomy. Expand
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TLDR
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A New Expander for Schlemm Canal Surgery in Primary Open-angle Glaucoma—Interim Clinical Results
TLDR
A new canal expander in circumferential viscocanalostomy (canaloplasty) for whites with primary open-angle glaucoma (POAG) without complications related to the device in this 1-year observation period is evaluated. Expand
Circumferential Viscocanalostomy and Suture Canal Distension (Canaloplasty) for Whites With Open-angle Glaucoma
TLDR
Canaloplasty seems to be a promising and effective surgical procedure in Whites with open-angle glaucoma and postoperative IOP levels are in the low-to-mid-teens. Expand
Suture Distension of Schlemm's Canal in Canaloplasty: An Anterior Segment Imaging Study
TLDR
The angles of the inner wall of Schlemm's canal generated by the suture stent were comparable between OCT and UBM and did not change significantly over time, suggesting the tensioning suture may contribute to IOP reduction. Expand
Three-year canaloplasty outcomes for the treatment of open-angle glaucoma: European study results
TLDR
Canaloplasty demonstrated significant and sustained intraocular pressure reductions accompanied by an excellent short- and long-term safety profile in adult patients with open-angle glaucoma. Expand
Canaloplasty for primary open-angle glaucoma: long-term outcome
TLDR
Canaloplasty produced a sustained long-term reduction of intraocular pressure pressure in black Africans with POAG independent of preoperative IOP and may be a true alternative to classic filtering surgery, in particular in patients with enhanced wound healing and scar formation. Expand
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Circumferential viscodilation and tensioning of Schlemm canal (canaloplasty) with temporal clear corneal phacoemulsification cataract surgery for open‐angle glaucoma and visually significant cataract: One‐year results
TLDR
Circumferential viscodilation and tensioning of Schlemm canal combined with clear corneal phacoemulsification and posterior chamber intraocular lens (IOL) implantation was a safe and effective procedure to reduce intraocular pressure in adult patients with OAG. Expand
Circumferential viscodilation of Schlemm's canal with a flexible microcannula during non-penetrating glaucoma surgery
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A pilot study was performed to evaluate the safety and performance of the flexible Ophthalmic Microcannula in accessing and dilating Schlemm's canal during non-penetrating surgery for the treatment of glaucoma. Expand
Primary viscocanalostomy versus trabeculectomy for primary open‐angle glaucoma: Three‐year prospective randomized clinical trial
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Primary trabeculectomy lowered IOP more than viscocanalostomy in POAG patients, however, the complication rate was lower in the viscOCanalOSTomy group. Expand
A Prospective Randomized Trial of Viscocanalostomy versus Trabeculectomy in Open-angle Glaucoma: A 1-year Follow-up Study
TLDR
In eyes with open-angle glaucoma, viscocanalostomy is less effective in reducing intraocular pressure than standard filtering surgery, however, postoperative complications are more frequent after filtering surgery. Expand
Viscocanalostomy versus trabeculectomy for primary open angle glaucoma: 4-year prospective randomized clinical trial
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Trabeculectomy was found to be more effective at lowering intraocular pressure than viscocanalostomy in POAG patients, and required less postoperative topical IOP-lowering medication. Expand
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TLDR
In terms of complete success and number of antiglaucomatous medications required postoperatively, IOP control appears to be better with trabeculectomy, and viscocanalostomy is associated with fewer early transient postoperative complications. Expand
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TLDR
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TLDR
Ab-interno goniotrabeculotomy appears to be a viable and safe surgical treatment for adult POAG and more extended follow-up, however, and a larger series of patients are needed to ascertain the actual effectiveness of this procedure in adultPOAG. Expand
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