Canalicular network morphology is the major determinant of the spatial distribution of mass density in human bone tissue: evidence by means of synchrotron radiation phase-contrast nano-CT.

@article{Hesse2015CanalicularNM,
  title={Canalicular network morphology is the major determinant of the spatial distribution of mass density in human bone tissue: evidence by means of synchrotron radiation phase-contrast nano-CT.},
  author={Bernhard Hesse and P{\'e}ter Varga and Max Langer and Alexandra Pacureanu and Susanne Schrof and Nils M{\"a}nnicke and Heikki Suhonen and Peter Maurer and Peter Cloetens and Françoise Peyrin and Kay Raum},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2015},
  volume={30 2},
  pages={346-56}
}
In bone remodeling, maturation of the newly formed osteonal tissue is associated with a rapid primary increase followed by a slower secondary increase of mineralization. This requires supply and precipitation of mineral into the bone matrix. Mineral delivery can occur only from the extracellular fluid via interfaces such as the Haversian system and the osteocyte pore network. We hypothesized that in mineralization, mineral exchange is achieved by the diffusion of mineral from the lacunar… CONTINUE READING
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