Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.

@article{Paulusma1999CanalicularMO,
  title={Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.},
  author={Coen C. Paulusma and Michael A van Geer and Raymond Evers and Marc Heijn and Roelof Ottenhoff and Piet Borst and Ronald P. J. Oude Elferink},
  journal={The Biochemical journal},
  year={1999},
  volume={338 ( Pt 2)},
  pages={393-401}
}
The canalicular multispecific organic anion transporter (cMOAT), a member of the ATP-binding cassette transporter family, mediates the transport of a broad range of non-bile salt organic anions from liver into bile. cMOAT-deficient Wistar rats (TR-) are mutated in the gene encoding cMOAT, leading to defective hepatobiliary transport of a whole range of substrates, including bilirubin glucuronide. These mutants also have impaired hepatobiliary excretion of GSH and, as a result, the bile flow in… CONTINUE READING
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