Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)

@inproceedings{KuemmerleDeschner2011CanakinumabA,
  title={Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)},
  author={Jasmin Beate Kuemmerle-Deschner and Eduardo Ramos and N Blank and Joachim Roesler and Sandra Daniela Felix and Thomas A. Jung and Kirstin Stricker and Abhijit Chakraborty and Stacey Tannenbaum and Andrew M Wright and Christiane M Rordorf},
  booktitle={Arthritis research & therapy},
  year={2011}
}
INTRODUCTION Cryopyrin-associated periodic syndrome (CAPS) represents a spectrum of three auto-inflammatory syndromes, familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease/chronic infantile neurological cutaneous and articular syndrome (NOMID/CINCA) with etiology linked to mutations in the NLRP3 gene resulting in elevated interleukin-1β (IL-1β) release. CAPS is a rare hereditary auto-inflammatory disease, which may… CONTINUE READING
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