Canagliflozin: Improving diabetes by making urine sweet.

  title={Canagliflozin: Improving diabetes by making urine sweet.},
  author={Mary Vouyiouklis},
  journal={Cleveland Clinic journal of medicine},
  volume={80 11},
Canagliflozin is the first sodium-glucose cotransport 2 (SGLT2) inhibitor approved in the United States for treating type 2 diabetes mellitus. This drug blocks reabsorption of glucose in the proximal tubule, lowering the renal threshold for glucose and thereby increasing glucose excretion. Its novel mechanism of action is insulin-independent. Trials have demonstrated reductions in fasting glucose and hemoglobin A1c levels, with the added benefit of weight loss. The adverse effects most often… CONTINUE READING
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