Can you hear me now? Regulating transcriptional activators by phosphorylation.

@article{Gardner2005CanYH,
  title={Can you hear me now? Regulating transcriptional activators by phosphorylation.},
  author={Kevin H Gardner and Marc R. Montminy},
  journal={Science's STKE : signal transduction knowledge environment},
  year={2005},
  volume={2005 301},
  pages={
          pe44
        }
}
Extracellular signals often modulate the expression of specific genetic programs by triggering the phosphorylation of relevant transcription factors (TFs). Phosphorylation in turn regulates such TFs by altering their cellular localization, DNA binding affinity, or transcriptional activity. Structural approaches have revealed how phosphorylation turns some TFs on or off; but less is known about how phosphorylation regulates other transcription factors in a graded manner that depends on signal… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Similar Papers

Loading similar papers…