Can we use erythrocytes for the study of the activity of the ubiquitous Na+/H+ exchanger (NHE-1) in essential hypertension?

@article{Orlov1998CanWU,
  title={Can we use erythrocytes for the study of the activity of the ubiquitous Na+/H+ exchanger (NHE-1) in essential hypertension?},
  author={Sergei N. Orlov and Sergei R. Kuznetsov and Nickolai I. Pokudin and Johanne Tremblay and Pavel Hamet},
  journal={American journal of hypertension},
  year={1998},
  volume={11 7},
  pages={774-83}
}
Both Na+/Li+ countertransport and electrochemical proton gradient (delta mu(H+))-induced Na+ and H+ fluxes are increased in erythrocytes from patients with essential hypertension. It was assumed that these abnormalities are related to ubiquitous (housekeeping) forms of the Na+/H+ exchanger (NHE-1). To examine this hypothesis, we compared kinetic and… CONTINUE READING