Can we produce true tolerance in patients with food allergy?

  title={Can we produce true tolerance in patients with food allergy?},
  author={M Cecilia Berin and Lloyd Hitoshi Mayer},
  journal={The Journal of allergy and clinical immunology},
  volume={131 1},
Immune tolerance is defined as nonresponsiveness of the adaptive immune system to antigens. Immune mechanisms preventing inappropriate immune reactivity to innocuous antigens include deletion of reactive lymphocytes and generation of regulatory T (Treg) cells. The normal response to food antigens is the generation of antigen-specific Treg cells. In patients with food allergy, the dominant immune response is a T(H)2-skewed T-cell response and the generation of food-specific IgE antibodies from B… CONTINUE READING