Can we predict the intracellular metabolic state of a cell based on extracellular metabolite data?

@article{Granucci2015CanWP,
  title={Can we predict the intracellular metabolic state of a cell based on extracellular metabolite data?},
  author={Ninna Granucci and Farhana R Pinu and Ting-Li Han and Silas Granato Villas-B{\^o}as},
  journal={Molecular bioSystems},
  year={2015},
  volume={11 12},
  pages={
          3297-304
        }
}
The analysis of extracellular metabolites presents many technical advantages over the analysis of intracellular compounds, which made this approach very popular in recent years as a high-throughput tool to assess the metabolic state of microbial cells. However, very little effort has been made to determine the actual relationship between intracellular and extracellular metabolite levels. The secretion of intracellular metabolites has been traditionally interpreted as a consequence of an… 
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