Can we conquer pain?
@article{Scholz2002CanWC,
title={Can we conquer pain?},
author={Joachim Scholz and Clifford J. Woolf},
journal={Nature Neuroscience},
year={2002},
volume={5 Suppl 1},
pages={1062-1067}
}Pain can be an adaptive sensation, an early warning to protect the body from tissue injury. By the introduction of hypersensitivity to normally innocuous stimuli, pain may also aid in repair after tissue damage. Pain can also be maladaptive, reflecting pathological function of the nervous system. Multiple molecular and cellular mechanisms operate alone and in combination within the peripheral and central nervous systems to produce the different forms of pain. Elucidation of these mechanisms is…
807 Citations
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References
SHOWING 1-10 OF 28 REFERENCES
Molecular mechanisms of nociception
- BiologyNature
- 2001
Efforts to determine how primary sensory neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.
Neuronal plasticity: increasing the gain in pain.
- BiologyScience
- 2000
Here, a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain is developed, identifying distinct forms of Plasticity, which are term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
The molecular dynamics of pain control
- Biology, PsychologyNature Reviews Neuroscience
- 2001
The cellular and neurobiological consequences of pain, especially those that are involved in the generation and maintenance of chronic pain, are emphasized, to significantly alter the approach to pain control and the development of new analgesics.
Neuropathic pain: aetiology, symptoms, mechanisms, and management
- Medicine, PsychologyThe Lancet
- 1999
Molecular mechanisms of cancer pain
- Biology, MedicineNature Reviews Cancer
- 2002
New insights into the basic neurobiology of cancer pain are now arising from animal models, and have the potential to fundamentally change the way that cancer pain is controlled.
The genetic mediation of individual differences in sensitivity to pain and its inhibition.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 1999
The present review summarizes the current progress toward the identification and characterization of particularly divergent populations and DNA sequence differences representing the differential alleles at pain-relevant genes in both humans and rodents.
Gabapentin: pharmacology and its use in pain management
- Medicine, BiologyAnaesthesia
- 2002
Gabapentin has been clearly demonstrated to be effective for the treatment of neuropathic pain in diabetic neuropathy and postherpetic neuralgia and its favourable side‐effect profile in various patient groups (including the elderly) and lack of drug interactions makes it an attractive agent.