Can valproic acid be an inducer of clozapine metabolism?

  title={Can valproic acid be an inducer of clozapine metabolism?},
  author={Francisco Javier Hern{\'a}ndez D{\'i}az and C B Eap and Nicolas Ansermot and Severine Crettol and Edoardo Spina and Jose de Leon},
  volume={47 3},
INTRODUCTION Prior clozapine studies indicated no effects, mild inhibition or induction of valproic acid (VPA) on clozapine metabolism. The hypotheses that (i) VPA is a net inducer of clozapine metabolism, and (ii) smoking modifies this inductive effect were tested in a therapeutic drug monitoring study. METHODS After excluding strong inhibitors and inducers, 353 steady-state total clozapine (clozapine plus norclozapine) concentrations provided by 151 patients were analyzed using a random… CONTINUE READING