Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?

  title={Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?},
  author={Nelson Siu Kei Lam and Xin Xin Long and Robert C. Griffin and Mu-kai Chen and James C G Doery},
  pages={1510 - 1520}
Abstract Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Although… 

Comparison of the efficacy of tea tree (Melaleuca alternifolia) oil with other current pharmacological management in human demodicosis: A Systematic Review

TTO (especially T4O) is found to be the most effective followed by metronidazole, ivermectin and permethrin in managing the Demodex mite population and the related symptoms and further research needs to be focused on the efficacy and drug delivery technology in order to develop alternative treatments with better side-effects profiles, less toxicity, lower risk of resistance and are more cost-effective.

Tea Tree Oil and Its Use in Aromatherapy

In this review historical, and morphological information about M. alternifolia plant, chemical properties related to TTO and the mechanism of antimicrobial, antiviral and antifungal actions will be explained, relying extensively on existing literature.

Antiparasitic Activity of Tea Tree Oil (TTO) and Its Components against Medically Important Ectoparasites: A Systematic Review

The promising outcomes observed in clinical studies provide enough evidence to justify the use of TTO in the pharmacotherapy of ectoparasitic infections, and the compelling in vitro activity of TOF seems to have translated well into the clinical environment.

The sensitivity of Demodex canis (Acari: Demodicidae) to the essential oil of Melaleuca alternifolia - an in vitro study.

The results showed that the higher the concentration of the oil, the more quickly its lethal effect occurred, and that the survival times in the controls were longer than in the different concentrations of melaleuca oil.

Tea tree (Melaleuca alternifolia) and its essential oil: antimicrobial, antioxidant and acaricidal effects in poultry production

Tea tree essential oils when supplemented in poultry diets have high positive effects regarding productivity performance, but this requires further field experiments to clarify standardisation of the material and effective inclusion levels.


Aim of this paper is to show antimicrobial, antifungal, antioxidant and acaricidal properties of tea tree (Melaleuca alternifolia). Tea tree exhibits wide spectrum of antimicrobial activity. Its mode

Study on the Therapeutic Effect of Melaleuca Oil on Mites in Patients with Dry Eye

Melaleuca Oil has a good killing effect on mites, while common eyelid cleaning (Iodophor, Cotrimoxazole, Chlorhexidine Acetate, Houttuynia cordata) has a weaker kill effect on eye mites than Melaleuca oil.

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

  • F. Forton
  • Medicine, Biology
    Dermatology and Therapy
  • 2020
Patients with only vascular symptoms of rosacea should be carefully examined for the presence of follicular scales as signs of Demodex overgrowth or pityriasis folliculorum so that these patients, at least, can be treated early with an acaricidal cream.

Characterization of tea tree oil nanoemulsion and its acute and subchronic toxicity.



A review of the toxicity of Melaleuca alternifolia (tea tree) oil.

Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

This review summarizes recent developments in understanding of the antimicrobial and anti-inflammatory activities of the tea tree oil and its components, as well as clinical efficacy.

Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites.

Terpinen-4-ol was the most potent ingredient in TTO and can be adopted in future formulations of acaricides to treat a number of ocular and cutaneous diseases caused by demodicosis.

Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes

The water-soluble components of tea tree oil can suppress pro-inflammatory mediator production by activated human monocytes and reduce the production in vitro of tumour necrosis factor-α, IL-1β and IL-10 by lipopolysaccharide-activated human peripheral blood monocytes.

Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol.

The results suggest that TTO has a potential role as a new topical acaricide and confirm terpinen-4-ol as the primary active component.

Melaleuca oil (tea tree oil) dermatitis.

Influence of tea tree oil (Melaleuca alternifolia) on the cattle tick Rhipicephalusmicroplus

It was able to show that both forms and all concentrations of M. alternifolia affected tick reproduction by inhibiting egg laying and hatching and that TTO nanoparticles potentiated the inhibitor effect of pure TTO on the reproduction of R. microplus.

Mechanism of Action of Melaleuca alternifolia (Tea Tree) Oil on Staphylococcus aureus Determined by Time-Kill, Lysis, Leakage, and Salt Tolerance Assays and Electron Microscopy

The predisposition to lysis, the loss of 260-nm-absorbing material, the lost of tolerance to NaCl, and the altered morphology seen by electron microscopy all suggest that tea tree oil and its components compromise the cytoplasmic membrane.