Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review

@article{Martin2014CanTQ,
  title={Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review},
  author={Angela Martin and Iris Krishna and Badell Martina and Amber Samuel},
  journal={Prenatal Diagnosis},
  year={2014},
  volume={34}
}
OBJECTIVE Previous studies have demonstrated an increase in the quantity of cell-free fetal DNA (cffDNA) before the onset of preeclampsia. [] Key Method Included studies evaluated cffDNA levels in pregnant women before the clinical onset of preeclampsia. RESULTS Thirteen studies met inclusion criteria. There was considerable heterogeneity between included studies, and all received a quality grade of C on the Grading of Recommendations Assessment, Development, and Evaluation scale.
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Maternal plasma cell‐free DNA in the prediction of pre‐eclampsia
To examine whether maternal plasma concentrations of total cell‐free (cf)DNA and fetal fraction at 11–13 and 20–24 weeks' gestation in pregnancies that subsequently develop pre‐eclampsia (PE) are…
Association between fetal fraction on cell‐free DNA testing and first‐trimester markers for pre‐eclampsia
To evaluate the association between fetal fraction on cell‐free DNA (cfDNA) testing and first‐trimester markers for pre‐eclampsia, and to investigate the possible association of low fetal fraction…
Can the quantity of cell‐free fetal DNA predict preeclampsia: a systematic review
TLDR
In Martin et al., the first name and family name of the third author were incorrectly identified and the quantity of cell-free fetal DNA predict preeclampsia: a systematic review.
Association between Levels of Total Cell-Free DNA and Development of Preeclampsia—A Literature Review
TLDR
Total cfDNA may play a role as a biochemical marker of PE, compared with fetal cfDNA, and large prospective studies with homogeneous populations and standardized methodology are needed to further confirm its predictive value.
Application of cell-free fetal DNA for early evaluation of preeclampsia to reduce maternal mortality by low-cost method – A prospective cohort study
TLDR
It is demonstrated that APGAR score, which is one of the indicators of physiologic maturity of the infant is severely affected by the causative factors of preeclampsia and cell-free fetal DNA quantification may be a promising marker for future adverse pregnancy outcome.
Quantification of circulating cell free fetal DNA and cell free total DNA in normal pregnancy and in pregnancy-related hypertension in Black South African Women.
Master of Medical Science in Medical Biochemistry and Chemical Pathology. University of KwaZulu-Natal, Durban 2016.
Circulating Maternal Total Cell-Free DNA, Cell-Free Fetal DNA and Soluble Endoglin Levels in Preeclampsia: Predictors of Adverse Fetal Outcome? A Cohort Study
TLDR
Incorporation of cf-DNA, cff-DNA and sEng into the prenatal care service should be considered as a serious addition for the screening and detection of adverse pregnancy outcomes in view of their significant elevations in cases of preeclamptic women whose babies ultimately suffered a poor outcome.
Cell-Free Fetal DNA for the Prediction of Pre-Eclampsia at the First and Second Trimesters: A Systematic Review and Meta-Analysis
TLDR
CffDNA quantification is a marker for predicting the development of both early-onset PE and ‘any PE’; however, it can probably only be used from the beginning of the second trimester, otherwise its predictive value is burdened with a DR that is too low or not significant.
At Preeclampsia Diagnosis, Total Cell‐Free DNA Concentration is Elevated and Correlates With Disease Severity
TLDR
In preeclampsia, higher total cfDNA correlates with earlier gestational age at delivery and higher systolic blood pressure, which may indicate increased release of cfDNA from maternal tissue injury.
Cell-free DNA as a potential biomarker for preeclampsia
  • A. C. Palei
  • Medicine, Biology
    Expert review of molecular diagnostics
  • 2021
TLDR
Findings justify the ongoing search for useful diagnostic and prognostic biomarkers that may be eventually targeted by novel therapies in PE and propose required studies to determine the role of cfDNA in mediating the pathogenesis of PE.
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TLDR
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TLDR
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Cell‐free fetal DNA (SRY locus) concentration in maternal plasma is directly correlated to the time elapsed from the onset of preeclampsia to the collection of blood
To determine (1) if fetal DNA (fDNA) in the maternal circulation in women affected by preeclampsia correlates with the time elapsed from the onset of symptoms to the time of blood collection, and (2)…
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The objective was to investigate whether women who develop preeclampsia can be identified in a routine analysis when determining fetal RHD status at 25 weeks' gestation in combination with PAPP‐A…
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This study aimed to quantitate cell free (cf) and cell free fetal (cff) DNA in maternal plasma by determining RASSF1A levels before and after enzyme digestion in women who subsequently developed…
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Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia.
Fetal fraction in maternal plasma cell‐free DNA at 11–13 weeks' gestation: relation to maternal and fetal characteristics
To examine the possible effects of maternal and fetal characteristics on the fetal fraction in maternal plasma cell‐free (cf) DNA at 11–13 weeks' gestation and estimate the proportion of pregnancies…
Correlation of fetal DNA levels in maternal plasma with Doppler status in pathological pregnancies
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Smoking in pregnancy is associated with increased total maternal serum cell‐free DNA levels
TLDR
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