Can the mechanisms of aluminum neurotoxicity be integrated into a unified scheme?

@article{Strong1996CanTM,
  title={Can the mechanisms of aluminum neurotoxicity be integrated into a unified scheme?},
  author={Michael J Strong and Ralph M. Garruto and J. G. Joshi and William R. Mundy and Timothy J. Shafer},
  journal={Journal of toxicology and environmental health},
  year={1996},
  volume={48 6},
  pages={599-613}
}
Regardless of the host, the route of administration, or the speciation, aluminum is a potent neurotoxicant. In the young adult or developmentally mature host, the neuronal response to Al exposure can be dichotomized on morphological grounds. In one, intraneuronal neurofilamentous aggregates are formed, whereas in the other, significant neurochemical and neurophysiological perturbations are induced without neurofilamentous aggregate formation. Evidence is presented that the induction of… CONTINUE READING
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