Can rehabilitation help ataxia?

  title={Can rehabilitation help ataxia?},
  author={Susanne M. Morton and Amy J. Bastian},
  pages={1818 - 1819}
Gait ataxia is one of the most common and debilitating motor disorders associated with cerebellar damage.1 Although some recovery occurs following a single, focal lesion (e.g., stroke, benign tumor),2 steady declines in gait and balance function are typical among individuals with cerebellar degenerative diseases. Currently, there are no pharmacologic treatments available to reverse or even substantially reduce motor disability caused by cerebellar degeneration. Thus, physical therapy forms the… 
24 Citations
General Management of Cerebellar Disorders: An Overview
  • D. Timmann
  • Psychology, Biology
    Handbook of the Cerebellum and Cerebellar Disorders
  • 2020
This chapter reviews the state of the art in medical intervention and rehabilitation, focusing on presenting new results on motor rehabilitation in cerebellar disease, and current studies in the area of motor learning – in combination with modern imaging techniques – in cere Bellar disease are described.
Consensus Paper: Management of Degenerative Cerebellar Disorders
There is consensus that evidence-based guidelines for the physiotherapy of degenerative cerebellar ataxia need to be developed, and future developments in physiotherapeutical interventions will be discussed including application of non-invasive brain stimulation.
Motor Training in Degenerative Spinocerebellar Disease: Ataxia-Specific Improvements by Intensive Physiotherapy and Exergames
It is demonstrated that high-intensity coordinative training might lead to a significant benefit in patients with degenerative ataxia, and preliminary recommendations for clinical practice are presented and open questions are articulate that might guide future studies on neurorehabilitation in degenerative spinocerebellar disease.
Update on intensive motor training in spinocerebellar ataxia: time to move a step forward?
Overall, data converge of the finding that intensive training is still based either on conventional rehabilitation protocols or whole-body controlled videogames (“exergames”), and short-term improvement is observed, which tends to be lost once the training is stopped.
Effects of repeated waist-pull perturbations on gait stability in subjects with cerebellar ataxia
The results revealed that participants with cerebellar ataxia could still rely on their learning capability to modify the gait towards a safer behavior, however, they could not take advantage from their residual learning capability while managing sudden and unexpected perturbations.
Consensus Paper: Neurophysiological Assessments of Ataxias in Daily Practice
The purpose of this consensus paper is to review electrophysiological abnormalities and to provide a guideline of neurophysiological assessments in cerebellar ataxias and agree that quantitative measures of ataxia are desirable as biomarkers.
Republished: A practical approach to late-onset cerebellar ataxia: putting the disorder with lack of order into order.
A diagnostic approach to ataxia developed around a case of sporadic, late-onset, slowly progressive ataxio is suggested, which can narrow the differential diagnosis.
Long‐term effects of coordinative training in degenerative cerebellar disease
Improvements in motor performance and achievements in activities of daily life 1 year after a 4 week intensive coordinative training, which was followed by a home training program persisted, indicating that in patients with degenerative cerebellar disease, continuous coordinatorative training leads to long‐term improvements, which translate to real world function.
Cerebellar involvement in learning to balance a cart-pole system
It is found that online learning is impaired while offline learning is partly preserved in cerebellar subjects, and the ability to predict the dynamics of the cart-pole system is an important factor for the reward-based skill acquisition process.


Intensive coordinative training improves motor performance in degenerative cerebellar disease
In patients with cerebellar ataxia, coordinative training improves motor performance and reduces ataxIA symptoms, enabling them to achieve personally meaningful goals in everyday life.
Friedreich ataxia.
  • M. Pandolfo
  • Medicine, Psychology
    Archives of neurology
  • 2008
Current knowledge of the Friedreich ataxia disease is reviewed and how it is contributing to the development of therapeutic approaches are reviewed.
Functional Recovery After Rehabilitation for Cerebellar Stroke
Functional outcome is best predicted by preexisting comorbidities and functional status at the time of discharge from acute hospitalization, and substantial improvement of mean FIM score frequently occurs after rehabilitation after cerebellar infarction.
Adaptation to lateral displacement of vision in patients with lesions of the central nervous system
The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral
Throwing while looking through prisms. I. Focal olivocerebellar lesions impair adaptation.
Normal human subjects and patients with lesions of the olivocerebellar system threw balls of clay at a visual target while wearing wedge prism spectacles to learn to throw in the direction of prism-bent gaze and adapted to hit the target.
Human cerebellar activity reflecting an acquired internal model of a new tool
A coherent computational theory is proposed in which the phylogenetically newer part of the cerebellum similarly acquires internal models of objects in the external world through motor learning.
Throwing while looking through prisms
This paper presents a meta-anatomy and neurobiology study of the immune system’s role in the development of central giant cell granuloma, a type of giant cell death.
Friedreich ataxia. Arch Neurol 2008;65: 1296–1303
  • Neurology 73 December
  • 2009