Can preconditioning reduce laparoscopy-induced tissue injury?

  title={Can preconditioning reduce laparoscopy-induced tissue injury?},
  author={Sezgin Y{\`i}lmaz and Tulay Koken and Çiğdem Tokyol and Ahmet Kahraman and Gokhan Akbulut and Mustafa Serteser and Coşkun Polat and Cigdem Gokce and Ozcan Gokce},
  journal={Surgical Endoscopy And Other Interventional Techniques},
Background: Pneumoperitoneum (P) created to facilitate laparoscopy (L) is associated with splanchnic perfusion, ischemia/reperfusion (I/R) injury, and oxidative stress. In this randomized controlled experimental study with blind outcome assessment, we evaluated the effect of preconditioning (PRE) on L-induced I/R injury. Methods: The subjects were 40 Sprague-Dawley male rats. P was created in all except controls, using carbondioxide (CO2) insufflation under a pressure of 15 mmHg. PRE consisted… CONTINUE READING