Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

@article{Guo2011CanNT,
  title={Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?},
  author={Jianfeng Guo and Ludovic Bourr{\'e} and D. Soden and Gerald C O'sullivan and Caitriona M O'driscoll},
  journal={Biotechnology advances},
  year={2011},
  volume={29 4},
  pages={402-17}
}
Cancer is one of the most wide-spread diseases of modern times, with an estimated increase in the number of patients diagnosed worldwide, from 11.3 million in 2007 to 15.5 million in 2030 (www.who.int). In many cases, due to the delay in diagnosis and high increase of relapse, survival rates are low. Current therapies, including surgery, radiation and chemotherapy, have made significant progress, but they have many limitations and are far from ideal. Although immunotherapy has recently offered… CONTINUE READING

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