Can new optical techniques for in vivo imaging and flow cytometry of the microcirculation benefit sickle cell disease research?

Abstract

Intravital microscopy is a valuable tool for research into sickle cell disease with studies being carried out on transgenic mice and human volunteers. The method has helped to develop an explanation for sickle crises based on cell adhesion to the vascular endothelium followed by logjamming of rigid sickle cells and has stimulated much research into new… (More)
DOI: 10.1002/cyto.a.21101

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