Can mitochondrial dysfunction be a predictive factor for oxidative stress in patients with obstructive sleep apnea?

Abstract

Mitochondrial dysfunction reflects a lifelong cumulative burden of cellular damage, and a decrease in mitochondrial DNA (mtDNA) copy number is associated with oxidative stress and chronic inflammation. The goal of this study was to assess whether mitochondrial dysfunction and a decrease in mtDNA copy number are common features of patients with obstructive sleep apnea syndrome (OSA). We compared mtDNA copy number between 20 healthy volunteers and 20 patients with OSA and investigated whether a significant attenuation of mtDNA copy number was observed in genomic DNA isolated from whole blood of OSA patients. Our observations lead to the hypothesis that mtDNA copy number is lower in whole blood DNA of OSA subjects and might be related to OSA severity, reflecting excessive oxidative stress in patients with OSA.

DOI: 10.1089/ars.2014.5955

Cite this paper

@article{Kim2014CanMD, title={Can mitochondrial dysfunction be a predictive factor for oxidative stress in patients with obstructive sleep apnea?}, author={Yoo-Suk Kim and Jin Wook Kwak and Kyu Eun Lee and Hyun Sang Cho and Su Jin Lim and Kyung Soo Kim and Hoon Yang and Hyun Jik Kim}, journal={Antioxidants & redox signaling}, year={2014}, volume={21 9}, pages={1285-8} }