Can misfolded proteins be beneficial? The HAMLET case

@article{PetterssonKastberg2009CanMP,
  title={Can misfolded proteins be beneficial? The HAMLET case},
  author={Jenny Pettersson-Kastberg and Sonja Aits and Lotta Gustafsson and Anki Mossberg and Petter Storm and Maria Trulsson and Filip Persson and K. Hun Mok and Catharina Svanborg},
  journal={Annals of Medicine},
  year={2009},
  volume={41},
  pages={162 - 176}
}
By changing the three-dimensional structure, a protein can attain new functions, distinct from those of the native protein. Amyloid-forming proteins are one example, in which conformational change may lead to fibril formation and, in many cases, neurodegenerative disease. We have proposed that partial unfolding provides a mechanism to generate new and useful functional variants from a given polypeptide chain. Here we present HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) as an… 
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