Can misfolded proteins be beneficial? The HAMLET case
@article{PetterssonKastberg2009CanMP, title={Can misfolded proteins be beneficial? The HAMLET case}, author={Jenny Pettersson-Kastberg and Sonja Aits and Lotta Gustafsson and Anki Mossberg and Petter Storm and Maria Trulsson and Filip Persson and K. Hun Mok and Catharina Svanborg}, journal={Annals of Medicine}, year={2009}, volume={41}, pages={162 - 176} }
By changing the three-dimensional structure, a protein can attain new functions, distinct from those of the native protein. Amyloid-forming proteins are one example, in which conformational change may lead to fibril formation and, in many cases, neurodegenerative disease. We have proposed that partial unfolding provides a mechanism to generate new and useful functional variants from a given polypeptide chain. Here we present HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) as an…
42 Citations
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