Can misfolded proteins be beneficial? The HAMLET case.

  title={Can misfolded proteins be beneficial? The HAMLET case.},
  author={Jenny Pettersson-Kastberg and Sonja Aits and Lotta Gustafsson and Anki Mossberg and Petter Storm and Maria Trulsson and Filip Persson and Ken H Mok and Catharina Svanborg},
  journal={Annals of medicine},
  volume={41 3},
By changing the three-dimensional structure, a protein can attain new functions, distinct from those of the native protein. Amyloid-forming proteins are one example, in which conformational change may lead to fibril formation and, in many cases, neurodegenerative disease. We have proposed that partial unfolding provides a mechanism to generate new and useful functional variants from a given polypeptide chain. Here we present HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) as an… CONTINUE READING