Can meta-analyses be trusted?

  title={Can meta-analyses be trusted?},
  author={Simon Giles Thompson and Stuart J. Pocock},
  volume={338 8775},
The enthusiasm for meta-analyses (or overviews) expressed by their proponents is not always shared by the broader medical community. To encourage constructive debate, we adopt a critical perspective on the conduct and interpretation of meta-analysis. We focus particularly on some of the statistical issues, especially heterogeneity between studies, and also on the extrapolation of meta-analysis findings to clinical practice. We conclude that meta-analysis is not an exact statistical science that… CONTINUE READING

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