Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory

@article{Cabeza2001CanMT,
  title={Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory},
  author={Roberto Cabeza and Stephen M. Rao and Anthony D. Wagner and Andrew R. Mayer and Daniel L. Schacter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98},
  pages={4805 - 4810}
}
  • R. Cabeza, S. Rao, D. Schacter
  • Published 3 April 2001
  • Psychology, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
To investigate the types of memory traces recovered by the medial temporal lobe (MTL), neural activity during veridical and illusory recognition was measured with the use of functional MRI (fMRI). Twelve healthy young adults watched a videotape segment in which two speakers alternatively presented lists of associated words, and then the subjects performed a recognition test including words presented in the study lists (True items), new words closely related to studied words (False items), and… 

Figures and Tables from this paper

Age Differences in Hippocampus-Cortex Connectivity during True and False Memory Retrieval
TLDR
The results underscored a role for the anterior hippocampus in true and false recognition, showing different functional patterns as a function of age and association strength.
Temporal and cerebellar brain regions that support both declarative memory formation and retrieval.
TLDR
Using event-related fMRI, young healthy subjects are scanned while they memorized real-world photographs and subsequently tried to recognize them within a series of new photographs to identify temporal and cerebellar brain areas that support both declarative memory formation and retrieval.
Neural Correlates of True Memory, False Memory, and Deception
TLDR
It is indicated that fMRI can detect the difference in brain activity between deception and false memory despite the fact that subjects respond with “I know” to novel events in both processes.
Differential contributions of prefrontal, medial temporal, and sensory-perceptual regions to true and false memory formation.
TLDR
The results suggest that FMF is an unintended consequence, or by-product, of elaborative semantic and visual encoding processes, which contributes to false remembering.
Hippocampal size is related to short-term true and false memory, and right fusiform size is related to long-term true and false memory
TLDR
This study provides the first evidence for the structural neural bases of individual differences in short-term and long-term true and false memories.
Age-related Differences in Brain Activity during True and False Memory Retrieval
TLDR
The results suggest that older adults' deficits in true memories reflect a decline in recollection processes mediated by the hippocampus, whereas their increased tendency to have false memories reflects their reliance on semantic gist mediated byThe lateral temporal cortex.
A Mini-Review of fMRI Studies of Human Medial Temporal Lobe Activity Associated with Recognition Memory
  • R. Henson
  • Psychology, Biology
    The Quarterly journal of experimental psychology. B, Comparative and physiological psychology
  • 2005
TLDR
This review considers event-related functional magnetic resonance imaging studies of human recognition memory that have or have not reported activations within the medial temporal lobes (MTL) to suggest a role for encoding processes during recognition tests.
Making Memories without Trying: Medial Temporal Lobe Activity Associated with Incidental Memory Formation during Recognition
TLDR
A novel approach to cross-participant alignment of neuroimaging data is presented that provides more precise localization and enhanced statistical power within regions such as the MTL.
...
...

References

SHOWING 1-10 OF 103 REFERENCES
Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: an fMRI study.
TLDR
Evidence is provided for an anterior-posterior functional differentiation within the MTL in processing novel and familiar verbal information and the finding of left MTL lateralization is consistent with lesion-based material-specific models of memory.
Late Onset of Anterior Prefrontal Activity during True and False Recognition: An Event-Related fMRI Study
TLDR
Event-related analyses of time course data show a relatively late onset and sustained duration for anterior prefrontal signal changes compared to signal changes in other activated regions, consistent with the idea that anterior prefrontal regions participate in postretrieval monitoring processes.
FMRI activity in the medial temporal lobe during recognition memory as a function of study‐test interval
The phenomenon of temporally graded retrograde amnesia (loss of information acquired before the onset of amnesia) suggests that the hippocampus, and possibly other medial temporal lobe (MTL)
Neural Correlates of Episodic Retrieval Success
TLDR
It is suggested that left frontal and parietal regions modulate activity based on the successful retrieval of information from episodic memory.
Recollection and Familiarity in Recognition Memory: An Event-Related Functional Magnetic Resonance Imaging Study
TLDR
It is suggested that the responses of different brain regions do dissociate according to the phenomenology associated with memory retrieval, and both R and K judgments for studied words and N judgments for unstudied words were associated with enhanced responses.
Retrieval Success is Accompanied by Enhanced Activation in Anterior Prefrontal Cortex During Recognition Memory: An Event-Related fMRI Study
TLDR
This method of instantiating retrieval success under conditions in which the target word had not been studied offers converging evidence for the claim that anterior-prefrontal cortex (among other regions) demonstrates enhanced activation during retrieval success.
Novelty and familiarity activations in PET studies of memory encoding and retrieval.
TLDR
A 'novelty/encoding hypothesis': novelty assessment represents an early stage of long-term memory encoding and elaborate, meaning-based encoding processes operate on the incoming information to the extent of its novelty, and therefore the probability ofLong-term storage of information varies directly with the novelty of the information.
Functional–Anatomic Study of Episodic Retrieval II. Selective Averaging of Event-Related fMRI Trials to Test the Retrieval Success Hypothesis
TLDR
Findings in right anterior prefrontal cortex go against the retrieval success hypothesis as formally proposed and provide an important constraint for interpretation of this region's role in episodic retrieval.
Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval.
TLDR
It is concluded that the prefrontal cortex, especially in the right hemisphere, is more active when a retrieval attempt succeeds than when it fails, consistent with the idea that the cortex supports processes that operate selectively on the products of memory retrieval.
Neuroanatomical correlates of retrieval in episodic memory: auditory sentence recognition.
TLDR
The prevalence of sulcal blood-flow changes may reflect extensive cortical gyrification; it may also indicate that memory-related processes rely on the densely packed neuropil of sulCal regions.
...
...