Can magnesium supplementation reduce seizures in people with epilepsy? A hypothesis

@article{Yuen2012CanMS,
  title={Can magnesium supplementation reduce seizures in people with epilepsy? A hypothesis},
  author={Alan W. C. Yuen and Josemir W Sander},
  journal={Epilepsy Research},
  year={2012},
  volume={100},
  pages={152-156}
}

Addressing potential role of magnesium dyshomeostasis to improve treatment efficacy for epilepsy: A reexamination of the literature

TLDR
To better understand the potential role of magnesium deficiency as a causal factor in epilepsy, more convenient and accurate measurement methods should to be developed and employed in randomized, controlled trials of oral magnesium supplementation in epilepsy.

The Role of Magnesium in Neurological Disorders

TLDR
Overall, the mechanistic attributes of magnesium in neurological diseases connote the macromineral as a potential target for neurological disease prevention and treatment.

Antiepileptic effect of magnesium: a new medical hypothesis

TLDR
Recent research progress from several aspects, such as relation between the low extracellular magnesium and epilepsy, abnormal magnesium concentration in the blood of epileptic patients, the antiepileptic effect of magnesium and possible mechanisms are reviewed.

Antiepileptic magnesium effect

Magnesium is a bioessential mineral. Magnesium ion is an important regulator of multiple ion channels' function. Magnesium has many neuroactive effects at cellular, network and whole body level.

Association of Serum Trace Elements and Minerals with Genetic Generalized Epilepsy and Idiopathic Intractable Epilepsy

TLDR
Low levels of calcium, magnesium, zinc and high levels of copper were found to be associated with genetic generalized epilepsy as well as idiopathic intractable epilepsy, and the patients with IIE were also found to have low levels of zinc.

Role of Magnesium Supplementation in Children with West Syndrome: A Randomized Controlled Clinical Trial

TLDR
Magnesium supplementation may be helpful in children with West syndrome and the clinical response was better in patients with normal initial serum magnesium levels in the intervention group than in other patients.

Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis.

TLDR
Knowing the effects of various antiepileptic drugs on trace element homeostasis could potentially be used to effectively guide appropriate therapeutic strategies in the future to treat patients with epilepsy.

‘Magnesium’-the master cation-as a drug—possibilities and evidences

  • A. MathewRajitha Panonnummal
  • Biology
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
  • 2021
TLDR
The roles of Mg2+ such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits.

Interictal Ionized Magnesium/ Total Serum Magnesium Ratio in Serbian Population with Drug Resistant Epilepsy- Whether is Severe Epilepsy in Fact Brain Injury?

TLDR
Predictors for the low interictal ionized magnesium/total serum magnesium ratio in this group of patients are: status epilepticus, older age in relation with longer suffering from epilepsy, more frequent seizures, and longest total intake of the phenobarbital.

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Therapeutic uses of magnesium.

TLDR
Because magnesium is excreted renally, it should be used with caution in patients with kidney disease and the use of magnesium for constipation and dyspepsia are accepted as standard care despite limited evidence.

Serum ionized magnesium and calcium levels in adult patients with seizures

TLDR
It is hypothesize that serum ionized levels of calcium (Ca2+) and magnesium (Mg2+) would be altered significantly during certain types of seizures, and was able to show significantly lower Mg2+ and higher ionized Ca2+/Mg 2+ ratios in seizure patients compared with a racially matched control group.

Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency

TLDR
Seizure threshold and latencies of the first jerk and first episode of clonic seizures increased over 3 weeks after peroral administration of Mg2+ salts and pyridoxine was most effective in this respect.

Serum magnesium levels in idiopathic epilepsy.

TLDR
Serum magnesium continues to be a sensitive early diagnostic index of idiopathic epilepsy and shows that serum magnesium does have a prognostic significance.

Magnesium treatment for patients with refractory status epilepticus due to POLG1-mutations

TLDR
Two previously healthy unrelated teenage girls, who both were admitted with generalized tonic-clonic seizures and visual symptoms leading to a DNA-supported diagnosis of juvenile-onset Alpers' syndrome, are described.

Disorders of magnesium metabolism in epilepsy

TLDR
Findings associated with the fact that Mg is a known depressor of the central nervous system and is involved in several enzymatic processes, including the synthesis of acetylcholine, were not appreciated by some authorities in the field of epilepsy.

Magnesium in major depression.

TLDR
It is considered that increasing intracellular concentration is a component of the antidepressant mechanism of sertraline and amytriptiline and maybe of other antidepressants, and a magnesium-induced stimulation of the RS is an important issue for treating anhedonia in patients with MD.

Plasma magnesium in adult Nigerian patients with epilepsy.

TLDR
Low plasma magnesium is associated with epilepsy, further studies may determine the influence of anti-epileptic drug therapy on plasma magnesium levels.

NMDA Receptor Complex Blockade by Oral Administration of Magnesium: Comparison with MK-801