Can laboratory reference strains mirror "real-world" pathogenesis?

  title={Can laboratory reference strains mirror "real-world" pathogenesis?},
  author={Christoph A Fux and Mark E. Shirtliff and Paul Stoodley and John William Costerton},
  journal={Trends in microbiology},
  volume={13 2},
The extraordinary plasticity of bacterial genomes raises concerns about the adequacy of laboratory-adapted reference strains for the study of "real-world" pathogenesis. Some laboratory strains have been sub-cultured for decades since their first isolation and might have lost important pathophysiological characteristics. Evidence is presented that bacteria rapidly adapt to in vitro conditions. Genomic differences between laboratory reference strains and corresponding low-passage clinical… CONTINUE READING
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