Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?

Abstract

Background Hyperinsulinemia, hyperglycemia, and obesity have been identified as risk factors for a variety of cancers [1]. Insulin inhibition (INSINH) can potentially limit cancer growth by factors including ketosis [2], and apoptosis secondary to fatty acid synthase inhibition [3] as well as intracellular potassium depletion [4]. Furthermore, dysregulation of many signaling proteins downstream of the insulin/IGF receptors such as PI3K/Akt, mTOR (inhibition) and AMPK (amplification) is a major area of drug target development [5,6]. We performed a four week INSINH diet in patients with advanced cancers to study safety/feasibility and also to examine a change inF-2-fluoro, 2-deoxyglucose (FDG) uptake on PET scan as a surrogate measure for tumor response.

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Cite this paper

@inproceedings{Fine2014CanII, title={Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?}, author={Eugene J. Fine and C. J. Segal-Isaacson and Silvia Herzkopf and Joseph A Sparano and M. Carmen Romano and R. D. Feinman and Nora Tomuta and Amanda F Bontempo and Abdissa Negassa}, year={2014} }