Can immunostimulatory agents enhance the abscopal effect of radiotherapy?

  title={Can immunostimulatory agents enhance the abscopal effect of radiotherapy?},
  author={Antonin Levy and Cyrus Chargari and Aur{\'e}lien Marabelle and Jean-Luc Perfettini and Nicolas Magn{\'e} and Eric Deutsch},
  journal={European journal of cancer},
Ionising radiation (IR) may harm cancer cells through a rare indirect out-of-field phenomenon described as the abscopal effect. Increasing evidence demonstrates that radiotherapy could be capable of generating tumour-specific immune responses. On the other hand, effects of IR also include inhibitory immune signals on the tumour microenvironment. Following these observations, and in the context of newly available immunostimulatory agents in metastatic cancers (anti-cytotoxic T lymphocyte… CONTINUE READING
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